Chondrocytes

Role of PPARα in down-regulating AGE-induced TGF-β and MMP-9 expressions in chondrocytes

J. Wang, Wang, G., Sun, G. W., Wang, J., Wang, G., and Sun, G. W., Role of PPARα in down-regulating AGE-induced TGF-β and MMP-9 expressions in chondrocytes, vol. 15, p. -, 2016.

Peroxisome proliferator-activated receptor is closely associated with the pathogenesis of osteoarthritis. The level of exogenous advanced glycation end-products (AGEs) in articular cartilage is highly associated with the severity of osteoarthritic lesions. However, their interactions and role in promoting osteoarthritisprogression remain unclear.

Upregulation of fibroblast growth factor 1 in the synovial membranes of patients with late stage osteoarthritis

R. Li, Wang, B., He, C. Q., Yang, Y. Q., Guo, H., Chen, Y., and Du, T. H., Upregulation of fibroblast growth factor 1 in the synovial membranes of patients with late stage osteoarthritis, vol. 14, pp. 11191-11199, 2015.

Osteoarthritis (OA) is a degenerative disease of the systemic joint that involves multiple cytokines and growth factors. Fibroblast growth factor 1 (FGF-1) is increased in patients with rheumatic arthritis. The aim of this study was to determine whether the expression and secretion of FGF-1 differed in synovial tissue from patients with late stage OA from that in normal tissues. We selected eight patients with late stage OA and eight healthy donors for this study.

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