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 Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis

C. Wang, Hu, D. Z., and Liu, J. Z.,  Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis, vol. 14, pp. 5485-5495, 2015.

To explore the potential cause of colorectal cancer metastasis, gene expression profiles, GSE21510, and miRNA expression profiles, GSE48074, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes in metastatic colorectal and non metastatic colorectal cancer compared with the normal samples were identified via the limma package in R. The differentially expressed miRNAs in colorectal cancer samples with lymph node metastasis compared with those without lymph node metastasis were screened out by the some method.

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