Children

Association of PTPN22 gene polymorphism with type 1 diabetes mellitus in Chinese children and adolescents

H. W. Liu, Xu, R. Y., Sun, R. P., Wang, Q., Liu, J. L., Ge, W., and Yu, Z., “Association of PTPN22 gene polymorphism with type 1 diabetes mellitus in Chinese children and adolescents”, vol. 14, pp. 63-68, 2015.

Previous studies have indicated that the protein tyrosine phosphatase nonreceptor type 22 gene (PTPN22) is associated with type 1 diabetes (T1DM) in the Caucasian population. In the present study, we investigated the relationship between PTPN22 genetic polymorphisms and T1DM in Chinese children. A total of 202 children and adolescents with T1DM and 240 healthy control subjects of Chinese Han origin were included in our analysis.

Safety of recombinant human granulocyte-macrophage colony-stimulating factor in healing pediatric severe burns

Y. F. Chi, Chai, J. K., Luo, H. M., Zhang, Q. X., and Feng, R., “Safety of recombinant human granulocyte-macrophage colony-stimulating factor in healing pediatric severe burns”, vol. 14, pp. 2735-2741, 2015.

We explored the safety of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) for healing burns in children. Subjects were randomly assigned to two groups: the experimental group received external rhGM-CSF gel, and the control group received rhGM-CSF gel matrix components, applied to the burn surface. Neither group was given any other drugs that promote wound healing. Each day we recorded the pulse, body temperature, and respiration status in the two groups.

Rapid sedation induced by fentanyl combined with propofol via an intrathecal chemotherapy injection for leukemia in children

X. Tian, Yang, Y. - H., Wei, H. - Y., Lao, J. - Q., Wang, H. - P., and Tian, Y. - Y., “Rapid sedation induced by fentanyl combined with propofol via an intrathecal chemotherapy injection for leukemia in children”, vol. 14, pp. 3687-3693, 2015.

This study explored the sedative and analgesic effects of fentanyl combined with propofol via an intrathecal chemotherapy injection for acute leukemia (acute lymphocytic leukemia or acute myelocytic leukemia) among children, to relieve pain and difficulty during intrathecal injection, improve treatment compliance, increase the success rate of single puncture, and reduce procedure failure, with the aim of developing a painless procedure for children with acute leukemia.

Disease indicators for sepsis and analysis of sepsis treatment in children using the continuous blood purification technique

J. P. Liu, Wang, X. W., and Qie, L. P., “Disease indicators for sepsis and analysis of sepsis treatment in children using the continuous blood purification technique”, vol. 14, pp. 5685-5693, 2015.

We analyzed disease severity, inflammation markers, and dynamic changes in cartilage glycoprotein 39 (YKL-40) and C-reactive protein (CRP) levels in children with sepsis before and after treatment with continuous blood purification (CBP). Study participants were 30 children with severe sepsis who were cured from the disease (experimental group) in the Children’s Serious Disease Center of In­ner Mongolia People’s Hospital between June 2012 and October 2013. Symptomatic CBP treatment was performed after disease severity scor­ing.

A case-control study on the risk factors of urinary calculus in Uyghur children in the Kashi region

H. C. Wang, Liu, C., He, H. Y., and Wang, M. X., “A case-control study on the risk factors of urinary calculus in Uyghur children in the Kashi region”, vol. 14, pp. 5862-5869, 2015.

The incidence of urinary calculus (UC) is very high in Uyghur children in the Kashi region of Xinjiang, China, which seriously affects the growth and life quality of these children. This study was aimed at investigating the risk factors of UC in Uyghur children in Kashi region. One hundred fifteen Uyghur children (age

Relationship between serum creatinine and obesity in children in Xinjiang, China

X. - M. Li, Ma, Y. - T., Xie, X., Yang, Y. - N., Li, X. M., and Zheng, Y. - Y., “Relationship between serum creatinine and obesity in children in Xinjiang, China”, vol. 13, pp. 2409-2416, 2014.

This study was designed to analyze the relationship between serum creatinine and body mass index in children in Xinjiang, China. We used a stratified sampling method to select 5222 children aged 6-17 years in 3 areas in Xinjiang and then measured serum creatinine with an enzymatic method. Our analysis showed that the mean serum creatinine of the various age groups differed, and the reference value increased gradually with age.

Effects of partial tonsillectomy on the immune functions of children with obstructive sleep apnea-hypopnea syndrome at early stage

Z. Y. Dai, Huang, D. Y., and Zhou, C. Y., “Effects of partial tonsillectomy on the immune functions of children with obstructive sleep apnea-hypopnea syndrome at early stage”, vol. 13, pp. 3895-3902, 2014.

The purpose of this study was to investigate the changes in the humoral and cellular immunity of children with obstructive sleep apnea-hypopnea syndrome and hypertrophy of tonsils before and after plasma-mediated temperature-controlled radiofrequency ablation treatment. Fifty-seven children suffering from obstructive sleep apnea-hypopnea syndrome and with hypertrophy of tonsils were enrolled in this study. Thirty-seven children were grouped in the partial tonsillectomy group and 20, in the tonsillectomy group.

High resolution computed tomography and classification of children with interstitial lung diseases

M. L. He, Lai, H., Cao, Y., Shuai, Y. Z., and Yu, S. C., “High resolution computed tomography and classification of children with interstitial lung diseases”, vol. 13, pp. 4241-4251, 2014.

High resolution computed tomography (HRCT) was used to classify children with interstitial lung diseases (ILD). Sixty children with ILD underwent HRCT in supine position under free-respiratory conditions during scanning. Children under 5 years old were sedated with chloral hydrate and the scanning scope was from the lung apex to the diaphragm. In children older than 5 years old, scans were obtained at three levels: aortic arch, tracheal carina, and 1 cm above the right diaphragm. Five infectious patients were followed up.

Effectiveness of bacterial infection-related cytokine profile (BIRCP) determination for monitoring pathogen infections in children with hemopathy in the bone marrow inhibition phase

X. D. Chen, Chen, B., Tang, Y. M., Song, H., Shi, S. W., Yang, S. L., Xu, W. Q., Pan, B. H., Zhao, F. Y., Zhao, N., Zhang, L. Y., and Mao, J. Q., “Effectiveness of bacterial infection-related cytokine profile (BIRCP) determination for monitoring pathogen infections in children with hemopathy in the bone marrow inhibition phase”, vol. 13, pp. 10622-10631, 2014.

Serum cytokine profiles were analyzed before and after infection in children with hemopathy in the bone marrow inhibition phase to explore the utility of cytokine variations for detecting infections.

Association between HLA-A and -B polymorphisms and susceptibility to Henoch-Schönlein purpura in Han and Mongolian children from Inner Mongolia

S. M. Ren, Yang, G. L., Liu, C. Z., Zhang, C. X., Shou, Q. H., Yu, S. F., Li, W. C., and Su, X. L., “Association between HLA-A and -B polymorphisms and susceptibility to Henoch-Schönlein purpura in Han and Mongolian children from Inner Mongolia”, vol. 11, pp. 221-228, 2012.

We examined a possible association between HLA-A and -B polymorphisms and susceptibility to Henoch-Schönlein purpura (HSP) in Han and Mongolian children in Inner Mongolia, through a case-control study. Two hundred and sixty-eight unrelated children were enrolled, including 56 Mongolian and 50 Han children with HSP, 66 healthy Mongolian and 96 healthy Han children as a control group. HLA-A and -B alleles were indentified by PCR-sequence-specific oligonucleotide analysis and were further analyzed by PCR-sequencing-based typing (SBT).

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