Chemotherapy

Glutathione S-transferase polymorphisms influence chemotherapy response and treatment outcome in breast cancer

J. Wang, Wang, T., Yin, G. - Y., Yang, L., Wang, Z. - G., and Bu, X. - B., Glutathione S-transferase polymorphisms influence chemotherapy response and treatment outcome in breast cancer, vol. 14, pp. 11126-11132, 2015.

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymor­phisms in the clinical response to chemotherapy and treatment outcome of patients with breast cancer. A total of 262 subjects were randomly selected from among patients with a histologically confirmed breast cancer. The genotypes of GSTM1, GSTT1, and GSTP1 IIe105Val poly­morphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis.

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