Chemoprevention

Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide

M. F. Magosso, Carvalho, P. C., Shneider, B. U. C., Pessatto, L. R., Pesarini, J. R., Silva, P. V. B., Correa, W. A., Kassuya, C. A. L., Muzzi, R. M., Oliveira, R. J., Magosso, M. F., Carvalho, P. C., Shneider, B. U. C., Pessatto, L. R., Pesarini, J. R., Silva, P. V. B., Correa, W. A., Kassuya, C. A. L., Muzzi, R. M., and Oliveira, R. J., Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide, vol. 15, p. -, 2016.

Acrocomia aculeata is a plant rich in antioxidant compounds. Studies suggest that this plant has anti-inflammatory, antidiabetic, and diuretic potential. We assessed the antigenotoxic, antimutagenic, immunomodulation, and apoptotic potentials of A. aculeata alone and in combination with an antitumor agent, cyclophosphamide. Swiss male mice (N = 140) were used.

Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis

S. D. Navarro, Mauro, M. O., Pesarini, J. R., Ogo, F. M., and Oliveira, R. J., Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis, vol. 14, pp. 1679-1691, 2015.

Resistant starch is formed from starch and its degradation products and is not digested or absorbed in the intestine; thus, it is characterized as a fiber. Because fiber intake is associated with the prevention of DNA damage and cancer, the potential antigenotoxic, antimutagenic, and anticarcinogenic capabilities of resistant starch from green banana flour were evaluated.

Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: A comparative study

L. E. S. Fedel-Miyasato, Formagio, A. S. N., Auharek, S. A., Kassuya, C. A. L., Navarro, S. D., Cunha-Laura, A. L., Monreal, A. C. D., Vieira, M. C., and Oliveira, R. J., Antigenotoxic and antimutagenic effects of Schinus terebinthifolius Raddi in Allium cepa and Swiss mice: A comparative study, vol. 13, pp. 3411-3425, 2014.

It is estimated that 60% of anticancer drugs are derived directly or indirectly from medicinal plants. Schinus terebinthifolius Raddi (Anacardiaceae) is traditionally used in Brazilian medicine to treat inflammation, ulcers, and tumors. Because of the need to identify new antimutagenic agents and to determine their mechanism of action, this study evaluated the chemopreventive activity of the methanolic extract from leaves of S.

Antigenotoxic and antimutagenic effects of glutamine supplementation on mice treated with cisplatin

J. R. Pesarini, Victorelli, S. G., Vicentini, A. P., Ferreira, L. K., Mauro, M. O., Matuo, R., Oliveira, J. R., Antoniolli, A. C. M. B., Mantovani, M. S., and Oliveira, R. J., Antigenotoxic and antimutagenic effects of glutamine supplementation on mice treated with cisplatin, vol. 13, pp. 4820-4830, 2014.

We evaluated the effects of glutamine on clastogenic and genotoxic damage prevention caused by the administration of cisplatin. Forty Swiss mice were divided into 8 experimental groups: G1 and G2, which were control groups; G3, G4, and G5, which were administered [2 doses of glutamine (orally)] separated by a 24-h period (150, 300, and 600 mg/kg, respectively), and a dose of phosphate-buffered saline by intraperitoneal injection; G6, G7, and G8, which were treated in the same manner as the previous groups, but received cisplatin rather than phosphate-buffered saline.

Evaluation of the antimutagenic activity and mode of action of carrageenan fiber in cultured meristematic cells of Allium cepa

C. I. Nantes, Pesarini, J. R., Mauro, M. O., Monreal, A. C. D., Ramires, A. D., and Oliveira, R. J., Evaluation of the antimutagenic activity and mode of action of carrageenan fiber in cultured meristematic cells of Allium cepa, vol. 13, pp. 9523-9532, 2014.

In this study, we evaluated the mutagenic and antimutagenic activities of carrageenan, a sulfated polysaccharide, and described its mode of action by using an Allium cepa assay. The results indicate that carrageenan is not mutagenic, rather it has significant chemopreventive potential that is mediated by both demutagenic and bio-antimutagenic activities. This compound can adsorb agents that are toxic to DNA and inactivate them. Additionally, carrageenan can modulate enzymes of the DNA repair system.

Mutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepa

I. Felicidade, Lima, J. D., Pesarini, J. R., Monreal, A. C. D., Mantovani, M. S., Ribeiro, L. R., and Oliveira, R. J., Mutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepa, vol. 13, pp. 9986-9996, 2014.

Polyphenolic compounds present in rosemary were found to have antioxidant properties, anticarcinogenic activity, and to increase the detoxification of pro-carcinogens. The aim of the study was to determine the effect the aqueous extract of rosemary (AER) on mutagenicity induced by methylmethane sulfonate in meristematic cells of Allium cepa, as well as to describe its mode of action. Anti-mutagenicity experiments were carried out with 3 different concentrations of AER, which alone showed no mutagenic effects.

Antimutagenic and anticarcinogenic effects of wheat bran in vivo

J. R. Pesarini, Zaninetti, P. T., Mauro, M. O., Carreira, C. M., Dichi, J. B., Ribeiro, L. R., Mantovani, M. S., and Oliveira, R. J., Antimutagenic and anticarcinogenic effects of wheat bran in vivo, vol. 12, pp. 1646-1659, 2013.

Previous studies in rodents treated with the pro-carcinogen 1,2-dimethylhydrazine suggested that the consumption of wheat bran protected against DNA damage in the colon and rectum. Based on this information, we evaluated wheat bran as a functional food in the prevention and treatment of colon cancer. We used the aberrant crypt focus assay to evaluate the anticarcinogenic potential of wheat bran (Triticum aestivum variety CD-104), the comet assay to evaluate its antigenotoxicity potential, and the micronucleus assay to evaluate its antimutagenic potential.

Evaluation of the antimutagenic and anticarcinogenic effects of inulin in vivo

M. O. Mauro, Monreal, M. T. F. D., Silva, M. T. P., Pesarini, J. R., Mantovani, M. S., Ribeiro, L. R., Dichi, J. B., Carreira, C. M., and Oliveira, R. J., Evaluation of the antimutagenic and anticarcinogenic effects of inulin in vivo, vol. 12, pp. 2281-2293, 2013.

The incidence of colorectal cancer is growing worldwide. The characterization of compounds present in the human diet that can prevent the occurrence of colorectal tumors is vital. The oligosaccharide inulin is such a compound. The aim of this study was to evaluate the antigenotoxic, antimutagenic and anticarcinogenic effects of inulin in vivo.

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