Chemokine

Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma

C. R. Tanyel, Cincin, Z. B., Gokcen-Rohlig, B., Bektas-Kayhan, K., Unur, M., and Cakmakoglu, B., Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma, vol. 12, pp. 5714-5720, 2013.

We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) method from peripheral blood samples of both groups. There was a statistically significant difference between the control and patient groups for CCR5 59029 A/G genotypes (P 0.05).

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