Cetuximab

Effects of cetuximab combined with afatinib on the expression of KDR and AQP1 in lung cancer

Y. H. Liu and Zhu, W. L., Effects of cetuximab combined with afatinib on the expression of KDR and AQP1 in lung cancer, vol. 14, pp. 16652-16661, 2015.

In this study, we examined the effect of cetuximab (epidermal growth factor receptor monoclonal antibody) combined with afatinib (epidermal growth factor receptorand human epidermal growth factor receptor 2 tyrosine kinase irreversible inhibitor) on the apoptosis of A549 cells and on kinase domain receptor (KDR) and aquaporin 1 (AQP1) expression in A549 cells. A549 cells were cultured in RPMI-1640 and then divided into 4 groups: control group, 1-nM cetuximab group, 25-μM afatinib group, and 1-nM cetuximab + 25-μM afatinib group.

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