Cervical intraepithelial neoplasia

Expression and clinical implications of enhancer of Zeste homolog 2 and p53 protein in squamous cell carcinoma and precancerous lesions in the cervix

H. M. Zhang, Chen, S. Q., Yao, S. Z., Zhang, H. M., Chen, S. Q., and Yao, S. Z., Expression and clinical implications of enhancer of Zeste homolog 2 and p53 protein in squamous cell carcinoma and precancerous lesions in the cervix, vol. 15, p. -, 2016.

We investigated the expression and clinical implications of enhancer of Zeste homolog 2 (EZH2) and p53 protein in cervical squamous cell carcinoma (SCC) and precancerous lesions. EZH2 and p53 expressions in SCC (168), cervical intraepithelial neoplasia (CIN)-I (19), CIN-II (35), and normal tissues (30) were detected by streptavidin-peroxidase-conjugation. The correlation between co-expression of EZH2 and p53 protein and the clinic pathological features and prognosis of SCC were discussed.

Evaluation of novel assays for the detection of human papilloma virus in self-collected samples for cervical cancer screening

Q. Chen, Du, H., Zhang, R., Zhao, J. H., Hu, Q. C., Wang, C., Wang, G. X., Tang, J. L., Wu, R. F., Chen, Q., Du, H., Zhang, R., Zhao, J. H., Hu, Q. C., Wang, C., Wang, G. X., Tang, J. L., and Wu, R. F., Evaluation of novel assays for the detection of human papilloma virus in self-collected samples for cervical cancer screening, vol. 15, p. -, 2016.

The aim of this study was to evaluate the performance of three new high-risk human papillomavirus (HPV) assays for primary cervical cancer screening, by using self-collected samples, and to identify an HPV assay that could overcome the major obstacles faced during large-scale population-based screening. Two hundred and ten women showing abnormal cervical cytology (and referred for a colposcopy) were recruited in this study.

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