Cervical cancer

Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis

X. L. Zhou and Wang, M., Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis, vol. 14, pp. 17059-17067, 2015.

Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of three proteins and their correlation with metastasis in cervical cancer by comparing them in different cervical lesions.

Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer

L. Han, Husaiyin, S., Wang, L., Wusainahong, K. D., Fu, X., and Niyazi, M., Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer, vol. 14, pp. 17252-17261, 2015.

In Uyghur women, mortality rates from cervical cancer are amongst the highest in the nation, and genetic susceptibility probably plays a role in the pathogenesis of the disease. We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women. Cervix tissue samples from 80 cases of cervical cancer and 80 cases of cervicitis were genotyped using polymerase chain reaction-sequence-based typing (PCR-SBT) for HLA-DQB1. Two hundred and ninety-six alleles were identified among the 160 cases.

Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer

P. Liu, Xin, F., and Ma, C. F., Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer, vol. 14, pp. 17995-18002, 2015.

Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy volunteers were recruited. Quantitative reverse transcription-polymerase chain reaction was performed to compare the serum levels miR-196a in all participants.

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