ApoE and S-100 expression and its significance in the brain tissue of rats with focal contusion
“ApoE and S-100 expression and its significance in the brain tissue of rats with focal contusion”, vol. 14, pp. 19275-19281, 2015.,
This study explored the effect of focal cerebral contusion on the expression of ApoE and S-100, and its significance in determining the time of brain injury. Based on a rat model of cerebral contusion, immunohistochemistry was used to analyze the expressions of S-100 and ApoE at different time points after injury. Thirty minutes following cerebral contusion, ApoE protein expression was significantly increased in cortex neurons (P < 0.01), and S-100 protein expression was significantly (P < 0.001) elevated 2 h after cerebral contusion.