Central nervous system

A novel mutation links to von Hippel-Lindau syndrome in a Chinese family with hemangioblastoma

X. M. Fu, Zhao, S. L., Gui, J. C., Jiang, Y. Q., Shen, M. N., Su, D. L., Gu, B. J., Wang, X. Q., Ren, Q. J., Yin, X. D., Huang, W. B., and Chen, X. G., A novel mutation links to von Hippel-Lindau syndrome in a Chinese family with hemangioblastoma, vol. 14, pp. 4513-4520, 2015.

Hemangioblastoma of the central nervous system occurs as sporadic tumors or as a part of von Hippel-Lindau (VHL) disease, an autosomal dominant hereditary tumor syndrome caused by a germline mutation in the VHL tumor suppressor gene. We screened a Chinese family with VHL for mutations in the VHL gene and evaluated a genetic test for diagnosing VHL disease and clinical screening of family members.

Cellular responses induced in vitro by iron (Fe) in a central nervous system cell line (U343MGa)

D. D. F. A. Alcântara, Ribeiro, H. F., Matos, L. A., Sousa, J. M. C., Burbano, R. R., and Bahia, M. O., Cellular responses induced in vitro by iron (Fe) in a central nervous system cell line (U343MGa), vol. 12, pp. 1554-1560, 2013.

Iron is the most important metallic chemical element on Earth. Poisoning caused by excessive iron in humans has been associated with pulmonary diseases including neoplasms caused by inhalation of iron oxides. The involvement of iron in neurodegenerative processes has already been described. DNA alterations are induced by iron and other chemical compounds containing this metal; however, the data are controversial and the mechanism by which iron induces mutagenesis remains unknown.

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