Cell cycle

Cytotoxicity and DNA damage in mouse macrophages exposed to silica nanoparticles

H. Yang, Wu, Q. Y., Lao, C. S., Li, M. Y., Gao, Y., Zheng, Y., Shi, B., Yang, H., Wu, Q. Y., Lao, C. S., Li, M. Y., Gao, Y., Zheng, Y., and Shi, B., Cytotoxicity and DNA damage in mouse macrophages exposed to silica nanoparticles, vol. 15, p. -, 2016.

Silica (SiO2) nanoparticles are being progressively applied in various applications, including cosmetics, food technology, and medical diagnostics. Although crystalline SiO2 is a known carcinogen, the carcinogenicity of SiO2 nanoparticles remains unclear. Here, we assessed the cytotoxic effects and DNA injury induced by exposure to various dosages of SiO2 nanoparticles at 0-2400 mg/mL (0-3200 mg/mL microscale SiO2 as positive control) for 24 h using RAW264.7 cells, followed by methyl tetrazolium (MTT) assay.

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