Cell apoptosis

Ulinastatin promotes T lymphocyte apoptosis in rats with severe acute pancreatitis via mitochondrial pathways

C. L. Wang, Li, N., Ma, T., Zhang, P., and You, S. Y., “Ulinastatin promotes T lymphocyte apoptosis in rats with severe acute pancreatitis via mitochondrial pathways”, vol. 14, pp. 5511-5518, 2015.

We explored the influence of ulinastatin on apoptosis of T lymphocytes in rats with severe acute pancreatitis (SAP) and the effect of ulinastatin on mitochondrial apoptosis pathways in spleen lymphocytes. Thirty-six Wistar rats were randomly divided into three groups (N = 12): a sham operated group, a SAP group, and an ulinastatin-treated SAP group. The SAP model was established by injecting 5% sodium taurocholate into the intrapancreatobiliary duct. Study rats were sacrificed after 24 h, and splenic lymphocytes were then collected.

FOXO1 is a tumor suppressor in cervical cancer

B. Zhang, Gui, L. S., Zhao, X. L., Zhu, L. L., and Li, Q. W., “FOXO1 is a tumor suppressor in cervical cancer”, vol. 14, pp. 6605-6616, 2015.

Forkhead box protein O1 (FOXO1) is an important transcriptional regulator of cell proliferation, and is considered essential for tumor growth and progression. However, the function of FOXO1 in human cervical cancer remains unclear. In this study, we investigated the role of FOXO1 in cervical cancer. Our results showed that FOXO1 expression was lower in cervical cancer than in cervical intraepithelial neoplasia and normal cervix by immunohistochemical analysis (P 2/M phase and upregulation of caspases-3 and -9 gene expression.

Reduction of galectin-3 expression reduces pituitary tumor cell progression

C. X. Huang, Zhao, J. N., Zou, W. H., Li, J. J., Wang, P. C., Liu, C. H., and Wang, Y. B., “Reduction of galectin-3 expression reduces pituitary tumor cell progression”, vol. 13, pp. 6892-6898, 2014.

We investigated the role of galectin 3 in the development and progression of pituitary tumors. We used RNA interference to depress Gal-3 gene expression; MTT and flow cytometry were applied to detect changes in cell proliferation and apoptosis levels in pituitary tumor cells. Expression of apoptosis-associated genes, Bcl-2 and Baxk was analyzed by Western blot.

Subscribe to Cell apoptosis