CCND1

Genetic polymorphisms of CCND1 and PTEN in progression of esophageal squamous carcinoma

Y. Jang, Lu, S. A., Chen, Z. P., Ma, J., Xu, C. Q., Zhang, C. Z., and Wang, J. J., Genetic polymorphisms of CCND1 and PTEN in progression of esophageal squamous carcinoma, vol. 12, pp. 6685-6691, 2013.

Cyclin D1 (CCND1) plays a significant role in G1-S transition of cell cycle, and phosphatase and a tensin homologue (PTEN) negatively regulate cell cycle through phosphatidylinositol 3-kinase (PI3K)/AKT signaling. CCND1 and PTEN genetic polymorphisms might induce susceptibility to the occurrence of esophageal squamous cell carcinoma (ESCC). Three hundred and four ESCC patients and 413 healthy controls from Anyang, China, were enrolled in this study.

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