Cattle

Mitochondrial DNA dynamics during in vitro culture and pluripotency induction of a bovine Rho0 cell line

L. V. F. Pessôa, Bressan, F. F., Chiaratti, M. R., Pires, P. R. L., Perecin, F., Smith, L. C., and Meirelles, F. V., Mitochondrial DNA dynamics during in vitro culture and pluripotency induction of a bovine Rho0 cell line, vol. 14, pp. 14093-14104, 2015.

Large number of cellular changes and diseases are related to mutations in the mitochondrial DNA copy number. Cell culture in the presence of ethidium bromide is a known way of depleting mitochondrial DNA and is a useful model for studying such conditions. Interestingly, the morphology of these depleted cells resembles that of pluripotent cells, as they present larger and fragmented mitochondria with poorly developed cristae.

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