Cathechol-o-methyltransferase

No evidence for association between DRD3 and COMT with schizophrenia in a Malay population

S. F. Tee, Tang, P. Y., and Loh, H. C., No evidence for association between DRD3 and COMT with schizophrenia in a Malay population, vol. 10, pp. 1850-1855, 2011.

Molecular components of the dopamine D3 receptor (DRD3) may play an important role in the pathophysiology of schizophrenia. Previous studies have demonstrated an association between DRD3 Ser9Gly and cathechol-o-methyltransferase (COMT, SNP = rs165656) polymorphisms and schizophrenia but the results were inconclusive. We investigated this apparent association between Ser9Gly (A/G) polymorphism and an intronic SNP (dbSNP or rs165656) in 261 Malay patients diagnosed with schizophrenia and 216 controls, using PCR-RFLP.

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