Y. J. Zhang, Zhong, X. P., Chen, Y., Liu, S. R., Wu, G., and Liu, Y. F.
, “Association between CASP-8 gene polymorphisms and cancer risk in some Asian population based on a HuGE review and meta-analysis”
, vol. 12, pp. 6466-6476, 2013.
Genetic variation in the CASP-8 gene reportedly can increase cancer susceptibility by regulating tumor cell proliferation and apoptosis. Several studies have investigated this possibility; however, the conclusions remain controversial. We made a Human Genome Epidemiology (HuGE) review and did a meta-analysis to explore the association between CASP-8 gene polymorphisms and cancer risk in Asian populations. Based on the inclusion criteria, 12 case-control studies comprising 7720 cancer cases and 9404 healthy controls were retrieved.