Case-control study

Genetic variation in WDR1 is associated with gout risk and gout-related metabolic indices in the Han Chinese population

L. J. Liu, Zhang, X. Y., He, N., Liu, K., Shi, X. G., Feng, T., Geng, T. T., Yuan, D. Y., Kang, L. L., Jin, T. B., Liu, L. J., Zhang, X. Y., He, N., Liu, K., Shi, X. G., Feng, T., Geng, T. T., Yuan, D. Y., Kang, L. L., Jin, T. B., Liu, L. J., Zhang, X. Y., He, N., Liu, K., Shi, X. G., Feng, T., Geng, T. T., Yuan, D. Y., Kang, L. L., and Jin, T. B., Genetic variation in WDR1 is associated with gout risk and gout-related metabolic indices in the Han Chinese population, vol. 15, p. -, 2016.

Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression. As a previous study identified that WD40 repeat protein 1 (WDR1) is associated with gout in populations of European descent, we sought to investigate its relationship with this disease in the Han Chinese population. We genotyped six WDR1 single nucleotide polymorphisms in 143 gout cases and 310 controls using Sequenom MassARRAY technology. The SPSS 16.0 software was used to perform statistical analyses.

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