Case-control study

A case-control study on the risk factors of urinary calculus in Uyghur children in the Kashi region

H. C. Wang, Liu, C., He, H. Y., and Wang, M. X., A case-control study on the risk factors of urinary calculus in Uyghur children in the Kashi region, vol. 14, pp. 5862-5869, 2015.

The incidence of urinary calculus (UC) is very high in Uyghur children in the Kashi region of Xinjiang, China, which seriously affects the growth and life quality of these children. This study was aimed at investigating the risk factors of UC in Uyghur children in Kashi region. One hundred fifteen Uyghur children (age

Association of XRCC5 polymorphisms with COPD and COPD-related phenotypes in the Han Chinese population: a case-control cohort study

B. Wang, Yang, J., Xiao, J., Liang, B., Zhou, H. X., Su, Z., Xu, S., Chen, H., Ma, C., Deng, J., Li, D., Ou, X., and Feng, Y., Association of XRCC5 polymorphisms with COPD and COPD-related phenotypes in the Han Chinese population: a case-control cohort study, vol. 13, pp. 7070-7078, 2014.

Genome-wide association studies (GWAS) and integrative genomic approaches have demonstrated significant associations between chronic obstructive pulmonary disease (COPD) and polymorphisms of the X-ray repair cross-complementing protein 5 gene (XRCC5) in non-Asian populations. We investigated whether XRCC5 polymorphisms might be associated with COPD susceptibility and COPD-related phenotypes in the Chinese Han population.

Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population

H. C. Liu, Zhang, J., Wong, S., Han, D., Zhao, H. S., and Feng, H. L., Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population, vol. 13, pp. 7133-7139, 2014.

Tooth agenesis is one of the most common anomalies of human dentition. Recent genetic studies have provided information regarding a number of genes related to both syndromic and non-syndromic forms of hypodontia. In a previous study, we found that polymorphism in rs11001553 of DKK1 was associated with hypodontia in the Chinese Han population. In this study, we extended this investigation to 89 individuals diagnosed with sporadic non-syndromic oligodontia (40 males and 49 females).

IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

G. Q. Sun, Wu, G. D., Meng, Y., Du, B., and Li, Y. B., IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population, vol. 13, pp. 7718-7724, 2014.

We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between January 2009 and May 2012. Genotyping of IL-6 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) was performed on a 384-well plate format using the Sequenom MassARRAY platform.

Advanced oxidation protein products as a biomarker of cutaneous lupus erythematosus complicated by nephritis: a case-control study

Z. Xie, Zhang, M., Zhao, B., Wang, Q., Li, J., Liu, Y. Y., and Chen, Y. H., Advanced oxidation protein products as a biomarker of cutaneous lupus erythematosus complicated by nephritis: a case-control study, vol. 13, pp. 9213-9219, 2014.

Oxidative stress is involved in the pathogenesis of lupus nephritis (LN). The current study investigated the significance of advanced oxidation protein products (AOPPs) as a biomarker of LN in patients with cutaneous lupus erythematosus. Ninety-two patients who initially presented with systemic lupus erythematosus were divided into the LN- and LN+ groups. Serum AOPP levels were determined, and the association between AOPP levels and LN was investigated in a case-control study.

Association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population

S. Honsawek, Deepaisarnsakul, B., Tanavalee, A., Yuktanandana, P., Bumrungpanichthaworn, P., Malila, S., and Saetan, N., Association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population, vol. 10, pp. 1674-1680, 2011.

Osteoarthritis is a chronic progressive degenerative joint disease characterized by age-related regressive change in articular cartilage. A single nucleotide polymorphism has been described at position -174 of the interleukin-6 (IL-6) promoter region, leading to three possible genotypes, GG, GC, and CC. We investigated a possible association of the IL-6 -174G/C gene polymorphism with knee osteoarthritis in a Thai population. Genotype distributions and allelic frequencies of the IL-6 -174G/C polymorphism were investigated in 115 knee osteoarthritis patients and 100 healthy controls.

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