Cartilage tissue engineering

Repair of cartilage defects in BMSCs via CDMP1 gene transfection

G. Wu, Cui, Y., Wang, Y. T., Yao, M., Hu, J., Li, J. X., Wang, Y., and Zhang, B., Repair of cartilage defects in BMSCs via CDMP1 gene transfection, vol. 13, pp. 291-301, 2014.

This study aimed at investigating the ability of cartilage-derived morphogenetic protein 1 (CDMP1) gene-transfected bone marrow mesenchymal stem cells (BMSCs) loaded on the poly(lactic-co-glycolic acid) (PLGA) scaffold for the repair of laryngeal cartilage defects and make a preliminary assessment of its repair effect. The mRNA and protein expressions of hCDMP1 were detected by reverse transcriptase-polymerase chain reaction and Western blotting. The expression of type II collagen (Col II) and glycosaminoglycan (GAG) were detected by immunohistochemistry.

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