Cardiovascular protection

Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats

S. M. Yang, Liu, J., and Li, C. X., Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats, vol. 13, pp. 8309-8319, 2014.

Hyperlipidemia is a well-established risk factor for the development of coronary atherosclerosis, while intermedin (IMD) has been identified as a novel calcitonin/calcitonin gene-related peptide family member involved in cardiovascular protection. However, whether IMD protects against hyperlipidemia-associated myocardial ischemia/reperfusion (MI/R) injury is unknown. We established a hyperlipidemia model using Sprague-Dawley rats, and created a MI/R condition by ligating the cardiac left circumflex artery.

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