Cardiomyocytes

Correlation between protein 4.1R and the progression of heart failure in vivo

Z. Wei, Yang, G., Xu, R., Zhu, C., He, F., Dou, Q., Tang, J., Wei, Z., Yang, G., Xu, R., Zhu, C., He, F., Dou, Q., and Tang, J., Correlation between protein 4.1R and the progression of heart failure in vivo, vol. 15, p. -, 2016.

We aimed to assess the protein 4.1R (4.1R) expression of the membrane skeleton in cardiomyocytes and to determine the potential role of 4.1R in the pathogenesis of heart failure (HF). Forty-two male mice were randomly divided into two groups: an HF group (N = 22) and control group (N = 20). The HF model was established by abdominal subcutaneous injection of 5 mg⋅kg-1⋅day-1 isopropyl adrenaline to the mice for 14 days. Electrocardiography was carried out and cardiac function was assessed by ultrasonic cardiogram.

Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2

N. I. Hanafi, Mohamed, A. S., J. Noor, M., N. Hasani, A. Hamid, Siran, R., Osman, N. J., S. Rahim, A., Kadir, S. H. Sheikh Abd, Hanafi, N. I., Mohamed, A. S., J. Noor, M., N. Hasani, A. Hamid, Siran, R., Osman, N. J., S. Rahim, A., and Kadir, S. H. Sheikh Abd, Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2, vol. 15, p. -, 2016.

Ursodeoxycholic acid (UDCA) is used to treat liver diseases and demonstrates cardioprotective effects. Accumulation of the plasma membrane sphingolipid sphingomyelin in the heart can lead to atherosclerosis and coronary artery disease. Sphingomyelinases (SMases) break down sphingomyelin, producing ceramide, and inhibition of SMases activity can promote cell survival. We hypothesized that UDCA regulates activation of ERK and Akt survival signaling pathways and SMases in protecting cardiac cells against hypoxia.

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