Cardiometabolic risk factor

β3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects

V. A. Genelhu, Francischetti, E. A., Duarte, S. F. P., Celoria, B. M. J., Oliveira, R. C., Cabello, P. H., and Pimentel, M. M. G., β3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects, vol. 9, pp. 1392-1397, 2010.

We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers were at greater risk for dysmetabolic phenotypes (odds ratio = 2.88, P = 0.03).

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