Cardiac myosin light-chain kinase

Protective role of neuregulin-1 toward doxorubicin-induced myocardial toxicity

Y. Q. Liu, Yang, M., Duan, C. H., Su, G. B., Wang, J. H., Liu, Y. F., and Zhang, J., Protective role of neuregulin-1 toward doxorubicin-induced myocardial toxicity, vol. 13, pp. 4627-4634, 2014.

The aim of this study was to investigate the role of the rat neuregulin-1 (NRG-1) protein in reducing doxorubicin (DOX)-induced myocardial toxicity and its underlying mechanism. The prokaryotic expression of the NRG-1 protein and the CCK8-determined activity of rat primary myocardial cells were evaluated under different DOX concentrations. Myocardial cells were divided into three groups: the control group, the 5 μM DOX (DOX5) group, and the DOX5 + NRG-1 group.

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