Cardiac hypertrophy

miR-96 inhibits cardiac hypertrophy by targeting growth factor receptor-bound 2

Y. Xia, Sheng, J., Liang, G. Y., Liu, D. X., Tang, Q., and Cheng, A. P., miR-96 inhibits cardiac hypertrophy by targeting growth factor receptor-bound 2, vol. 14, pp. 18958-18964, 2015.

Increasing evidence has indicated that microRNAs are involved in the pathogenesis of cardiac hypertrophy. However, whether miR-96 is involved in heart diseases, particularly cardiac hypertrophy, remains unclear. In this study, we found that miR-96 is a negative regulator of cardiac hypertrophy. In primary cardiomyocytes, overexpression of miR-96 inhibited phenylephrine-induced cardiomyocyte hypertrophy and decreased the mRNA expression of cardiac hypertrophy markers such as atrial natriuretic factor and β-myosin heavy chain.

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