miR-96 inhibits cardiac hypertrophy by targeting growth factor receptor-bound 2
“miR-96 inhibits cardiac hypertrophy by targeting growth factor receptor-bound 2”, vol. 14, pp. 18958-18964, 2015.,
Increasing evidence has indicated that microRNAs are involved in the pathogenesis of cardiac hypertrophy. However, whether miR-96 is involved in heart diseases, particularly cardiac hypertrophy, remains unclear. In this study, we found that miR-96 is a negative regulator of cardiac hypertrophy. In primary cardiomyocytes, overexpression of miR-96 inhibited phenylephrine-induced cardiomyocyte hypertrophy and decreased the mRNA expression of cardiac hypertrophy markers such as atrial natriuretic factor and β-myosin heavy chain.