Cancer risk

Association of the interleukin-6 gene -572G/C polymorphism with cancer risk: a meta-analysis

Q. Zhao, Zhang, B., Chen, Y., Li, M., Zhao, X., Fan, H., and Li, S. M., Association of the interleukin-6 gene -572G/C polymorphism with cancer risk: a meta-analysis, vol. 14, pp. 16921-16928, 2015.

The -572G/C polymorphism in interleukin-6 (IL-6) gene is associated with the development of cancer. However, previous studies have shown conflicting results; therefore, the association must be verified by an appropriate meta-analysis. For this purpose, we performed a literature search of the PubMed database to identify all reports on association between the IL-6 -572G/C polymorphism and cancer risk. Summary odds ratios (OR) and 95% confidence intervals (95%CI) were calculated for the -572G/C polymorphism and cancer in a fixed- and random-effect model, as appropriate.

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