Calcium

Mechanisms of cytotoxicity induced by the anesthetic isoflurane: the role of inositol 1,4,5-trisphosphate receptors

W. - H. Zhai, Zhao, J., Huo, S. - P., Chen, X. - G., Li, Y. - D., Zhang, Z. - L., Yu, L. - L., Song, S., and Wang, Q. - J., “Mechanisms of cytotoxicity induced by the anesthetic isoflurane: the role of inositol 1,4,5-trisphosphate receptors”, vol. 14, pp. 6929-6942, 2015.

Isoflurane can induce widespread cytotoxicity. We hypothesized that isoflurane induces apoptosis partly by causing excessive calcium release from the endoplasmic reticulum (ER) via direct activation of inositol 1,4,5-trisphosphate receptors (IP3R). Rat pheochromocytoma cells cultured for seven days with nerve growth factor were divided into four groups: control group (C), IP3R antagonist group (X), isoflurane group (I) and isoflurane + IP3R antagonist group (I+X). Groups I and I+X were treated with 1 MAC isoflurane for 12 h.

Skeletal muscle calcium channel ryanodine and the development of pale, soft, and exudative meat in poultry

F. G. Paião, Ferracin, L. M., Pedrão, M., Kato, T., and Shimokomaki, M., “Skeletal muscle calcium channel ryanodine and the development of pale, soft, and exudative meat in poultry”, vol. 12, pp. 3017-3027, 2013.

The development of pale, soft, and exudative (PSE) breast fillet meat has become an economic burden for the poultry industry worldwide. PSE meat results in 1.0-1.5% loss in moisture and carcass weight, and a 2010 estimate of the Brazilian annual production put the economic loss due to PSE at over US$30 million. In the USA, PSE has caused an annual loss of up to US$200 million to the poultry industries. The underlying causes of the color abnormality in PSE meat are not fully understood.

Expression of 1alpha-HYD and 24-HYD in bovine kidney mediated by vitamin D3 supplementation

L. R. Rezende, Delgado, E. F., Júnior, A. R. L., Gasparin, G., Jorge, E. C., Mourão, G. B., and Coutinho, L. L., “Expression of 1alpha-HYD and 24-HYD in bovine kidney mediated by vitamin D3 supplementation”, vol. 12, pp. 6611-6618, 2013.

In order to better understand vitamin D3 in cattle metabolism, we quantified 1alpha-HYD and 24-HYD gene expression. In the kidneys of 35 male Nellore cattle, these were divided into a control group and two treatment groups (2 x 106 international units of vitamin D3 administered for 2 or 8 consecutive days pre-slaughter).

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