Cadmium exposure

Expression profiles of DNA repair-related genes in rat target organs under subchronic cadmium exposure

Y. X. Lei, Lu, Q., Shao, C., He, C. C., Lei, Z. N., and Lian, Y. Y., Expression profiles of DNA repair-related genes in rat target organs under subchronic cadmium exposure, vol. 14, pp. 515-524, 2015.

We aimed to evaluate the toxicity of long-term exposure to different cadmium (Cd) doses in rats and expression profiles of DNA repair-related genes. The model rats were exposed to different concentrations of CdCl2 for 3 months, and 5 DNA repair-related genes - hMSH2, MLH1, XRCC1, hOGG1, ERCC1 - were cloned in different tissues, including the liver, kidney, heart, and lung. Accumulated amounts of Cd were detected in the tissues.

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