C1GALT1 gene; Gene polymorphism; IgA nephropathy; Uyghur

Association between C1GALT1 variants and genetic susceptibility to IgA nephropathy in Uygur

W. L. Li and Lu, C., Association between C1GALT1 variants and genetic susceptibility to IgA nephropathy in Uygur, vol. 14, pp. 5327-5333, 2015.

Immunoglobulin A (IgA) nephropathy (IgAN) is a common form of primary glomerulonephritis characterized by diffuse glomerular mesangial IgA1 deposition leading to mesangial proliferation and chronic glomerular inflammation. Analyses of serum IgA1 from IgAN patients revealed abnormal galactosylation of the O-linked carbohydrate moieties of IgA that may result from altered activity in the core of 1 b1,3-galactosyltransferase (C1GalT1).

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