Breast cancer

Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer

X. Huang, Yang, Y., Guo, Y., Cao, Z. L., Cui, Z. W., Hu, T. C., and Gao, L. B., Association of a let-7 KRAS rs712 polymorphism with the risk of breast cancer, vol. 14, pp. 16913-16920, 2015.

Breast cancer (BC) is a common malignancy affecting women, with increasing incidences of this disease in China every year. Recent studies have extensively investigated a single nucleotide polymorphism in the let-7 miRNA binding site of the 3'-untranslated region of KRAS mRNA. The aim of this study was to determine the genotype frequency of the KRAS rs712 polymorphism, and evaluate its effect on BC risk. This hospital-based case-control study comprised 228 patients with histologically confirmed BC and 251 healthy controls.

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