Breast cancer

Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis

P. Yuan, Yuan, L., Xu, B. L., Wang, C. Z., Yang, H. Z., and Li, Y., “Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis”, vol. 14, pp. 16675-16681, 2015.

The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism.

Mitochondrial ND3 G10398A mutation: a biomarker for breast cancer

Y. Yu, Lv, F., Lin, H., Qian, G., Jiang, Y. S., Pang, L. X., Wang, Y. P., Wang, X. F., Kang, Y. M., Li, C. B., Liu, Q., Xu, J. Z., and You, W., “Mitochondrial ND3 G10398A mutation: a biomarker for breast cancer”, vol. 14, pp. 17426-17431, 2015.

Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and molecular datasets from case-control studies to determine the association between the G10398A mutation and breast cancer. We further used the Phylotree to determine the haplogroups of this mutation.

miR-125a-5p expression is associated with the age of breast cancer patients

H. He, Xu, F., Huang, W., Luo, S. Y., Lin, Y. T., Zhang, G. H., Du, Q., and Duan, R. H., “miR-125a-5p expression is associated with the age of breast cancer patients”, vol. 14, pp. 17927-17933, 2015.

Dysregulated miR-125 observed in multiple cancer types has suggested that it is involved in malignant proliferation and invasion. However, the clinical significance of miR-125 in human breast cancer (BC) has not yet been fully elucidated. In the present study, the expression of miR-125a-5p/3p and miR-125b in 143 pairs of BC and normal adjacent tissues (NATs) was measured by real-time quantitative PCR, and the correlation between expression and clinicopathological features was explored.

AGER genetic polymorphisms increase risks of breast and lung cancers

N. C. Yin, Lang, X. P., Wang, X. D., and Liu, W., “AGER genetic polymorphisms increase risks of breast and lung cancers”, vol. 14, pp. 17776-17787, 2015.

We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases.

Direct preparation protocol to obtain mitotic chromosomes from canine mammary tumors

C. S. D. Morais, Affonso, P. R. A. M., Bitencourt, J. A., and Wenceslau, A. A., “Direct preparation protocol to obtain mitotic chromosomes from canine mammary tumors”, vol. 14, pp. 19389-19395, 2015.

Currently, mammary neoplasms in female canines are a serious problem in veterinary clinics. In addition, the canine species is an excellent disease model for human oncology because of the biological and genetic similarities between the species. Cytogenetics has allowed further study of the characterization of neoplasms in canines. We hypothesized that the use of a direct preparation protocol for mitotic chromosome analysis would provide a simple and low cost protocol for use in all laboratories.

S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation

Y. J. Sun, Wang, X. K., and Li, B. J., “S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation”, vol. 14, pp. 9244-9252, 2015.

We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2 in breast cancer patient tissues and normal breast tissues was detected by western blotting analysis and reverse transcription-polymerase chain reaction.

Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis

Y. Zhang, Yu, Y. F., Wang, J. Z., and Jia, H., “Vascular endothelial growth factor +405G/C and -2578C/A polymorphisms and breast cancer risk: a meta-analysis”, vol. 14, pp. 8909-8918, 2015.

This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and screening, 9 eligible case-control studies were included in this meta-analysis.

Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population

J. Dang, Peng, L., Zhong, H. J., and Huo, Z. H., “Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population”, vol. 14, pp. 10258-10266, 2015.

The androgen receptor (AR) is involved in the differentiation and growth of breast cancer. Genetic markers in the AR gene have a plausible role in modulating the risk of breast cancer. In this study, we studied the association of breast cancer and the trinucleotide repeat polymorphism (CAG)n in exon 1 of the AR gene in 202 patients with breast cancer and 183 healthy controls from our hospital (Yinchuan, China). Repeat lengths were determined by fluorescent DNA fragment analysis using the ABI GeneScan software and DNA sequencing.

Predictive potential role of glutathione S-transferase polymorphisms in the prognosis of breast cancer

X. Wang and Huang, Z. H., “Predictive potential role of glutathione S-transferase polymorphisms in the prognosis of breast cancer”, vol. 14, pp. 10236-10241, 2015.

The current study aimed at evaluating the associa­tion between GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms and clinical response to chemotherapy and treatment outcome of breast cancers patients. Genotyping of GSTP1 rs1695, GSTT1 deletion, and GSTM1 deletion was performed by Polymerase Chain Reaction Restriction Fragment Length Polymor­phism (PCR-RFLP) assay.

Gene expression profile in breast cancer comprising predictive markers for metastatic risk

S. Sirirattanakul, Wannakrairot, P., Tencomnao, T., and Santiyanont, R., “Gene expression profile in breast cancer comprising predictive markers for metastatic risk”, vol. 14, pp. 10929-10936, 2015.

Quantitative multiplex reverse transcriptase-polymerase chain reaction was developed for the simultaneous detection of multiple-gene expression levels of formalin-fixed, paraffin-embedded breast cancer samples. Candidate genes were selected from previous microarray data relevant to breast cancer markers that had the potential to serve as predictive markers for metastatic risk. This multiplex gene set included 11 candidate and 3 housekeeping genes, and the aim was to predict breast cancer progression based on lymph node involvement status.

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