Breast cancer

Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development

T. Zara-Lopes, Gimenez-Martins, A. P. A., Nascimento-Filho, C. H. V., Castanhole-Nunes, M. M. U., Galbiatti-Dias, A. L. S., Padovani-Júnior, J. A., Maniglia, J. V., Francisco, J. L. E., Pavarino, E. C., Goloni-Bertollo, E. M., Zara-Lopes, T., Gimenez-Martins, A. P. A., Nascimento-Filho, C. H. V., Castanhole-Nunes, M. M. U., Galbiatti-Dias, A. L. S., Padovani-Júnior, J. A., Maniglia, J. V., Francisco, J. L. E., Pavarino, E. C., and Goloni-Bertollo, E. M., “Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development”, vol. 15, p. -, 2016.

Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR A2756G, rs1805087) polymorphisms and risk for thyroid and breast cancer.

Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women

Z. Pan, Fu, Z., Song, Q., Cao, W., Cheng, W., Xu, X., Pan, Z., Fu, Z., Song, Q., Cao, W., Cheng, W., and Xu, X., “Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women”, vol. 15, p. -, 2016.

Sex hormones play important roles in breast cancer (BC) development. This study investigated associations between BC risk and hormone-related gene variants in Chinese women. In a cohort of 336 patients with histopathologically confirmed BC and 390 age-matched controls, we genotyped seven single nucleotide polymorphisms (SNPs) in five hormone-related genes: estrogen receptor-α (ESR1), aromatase (CYP19), catechol-O-methyl transferase (COMT), sex hormone-binding globulin (SHBG), and glutathione S-transferase (GSTP1).

Expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 in breast cancer

L. Zhang, Yang, W. P., Wu, L. Y., Zhu, X., Wei, C. Y., Zhang, L., Yang, W. P., Wu, L. Y., Zhu, X., and Wei, C. Y., “Expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 in breast cancer”, vol. 15, p. -, 2016.

Our objective was to explore the expression and clinical significance of Kelch-like epichlorohydrin-associated protein 1 (Keap1) in breast cancer tissue. Eighty-one breast cancer patients having undergone surgical treatment in our hospital between March 2002 and December 2008 were enrolled in this study. Normal tissue adjacent to tumors was used for the control samples. Diagnoses for all patients were confirmed by postoperative pathological examination.

Tristetraprolin: a novel mediator of the anticancer properties of resveratrol

C. Li, Tang, C., He, G., Li, C., Tang, C., and He, G., “Tristetraprolin: a novel mediator of the anticancer properties of resveratrol”, vol. 15, p. -, 2016.

Resveratrol is a natural compound that exhibits anticancer properties. Previous studies have proved that it can inhibit the proliferation of breast cancer cell lines and upregulate some cytokines such as cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). The initiation and progression of cancer are associated with the abnormal expression of multiple cytokines. Tristetraprolin (TTP), an mRNA-binding protein, is one of the key proteins that participate in regulating cytokine expression.

Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population

S. H. Ma, Ling, F. H., Sun, Y. X., Chen, S. F., Li, Z., Ma, S. H., Ling, F. H., Sun, Y. X., Chen, S. F., and Li, Z., “Investigation on the role of XPG gene polymorphisms in breast cancer risk in a Chinese population”, vol. 15, p. -, 2016.

We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of XPG rs2094258, rs751402, and rs17655 was performed using polymerase chain reaction-restriction fragment length polymorphism.

Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis

M. Kuang, Xu, W., Cao, C. X., Shen, L. L., Chang, J., Zhang, X. L., Chen, J. F., Tang, C. J., Kuang, M., Xu, W., Cao, C. X., Shen, L. L., Chang, J., Zhang, X. L., Chen, J. F., and Tang, C. J., “Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis”, vol. 15, p. -, 2016.

Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this meta-analysis was conducted to obtain a comprehensive estimation of this association. A total of 20,615 cases and 20,481 controls from thirty-six case-control trials were extracted from an online literature survey.

Molecular-level effects of eribulin and paclitaxel on breast cancer based on differential co-expression network analysis

J. Qin, Chen, Y. H., Qin, J., and Chen, Y. H., “Molecular-level effects of eribulin and paclitaxel on breast cancer based on differential co-expression network analysis”, vol. 15, p. -, 2016.

We investigated the effects of eribulin and paclitaxel on breast cancer (BC) by exploring molecular biomarkers and pathways. Co-expression networks were constructed by differentially co-expressed genes and links, and centralities were analyzed to explore the hub genes. Pathway-enrichment analysis was performed. The hub genes were validated using the polymerase chain reaction and western blotting. A total of 132 and 153 differentially expressed genes were identified in BC cell lines treated with eribulin and paclitaxel, respectively.

Roles of microRNA-221/222 in type 2 diabetic patients with post-menopausal breast cancer

M. Y. Li, Pan, S. R., Qiu, A. Y., Li, M. Y., Pan, S. R., and Qiu, A. Y., “Roles of microRNA-221/222 in type 2 diabetic patients with post-menopausal breast cancer”, vol. 15, p. -, 2016.

The aim of the research was to examine the expression level of microRNA221/222 (miR-221/222) in the serum of patients with type 2 diabetes mellitus (T2DM) who are also diagnosed with post-menopausal breast cancer. We aimed to evaluate the differences in microRNA expression in patients with T2DM alone, patients with post-menopausal breast cancer alone, and patients with both T2DM and post-menopausal breast cancer.

Protein-protein interaction between ezrin and p65 in human breast cancer cells

R. Tang, Li, F. X., Shao, W. F., Wen, Q. S., Yu, X. R., Xiong, J. B., Tang, R., Li, F. X., Shao, W. F., Wen, Q. S., Yu, X. R., and Xiong, J. B., “Protein-protein interaction between ezrin and p65 in human breast cancer cells”, vol. 15, p. -, 2016.

Our study aimed to investigate the co-localization and protein-protein interactions between ezrin and p65 in human breast cancer cells. Liquid chromatography-mass spectrometry (LCMS) was used to uncover novel protein interactions with ezrin in MDA-MB-231 cells. Endogenous co-immunoprecipitation was used to validate protein-protein interactions between ezrin and p65 in MDA-MB-231. Exogenous interactions between ezrin and p65 were validated in MDA-MB-231 cells via Flag-ezrin and HA-p65 co-transfection and followed by co-immunoprecipitation.

Methylation of the RASSFIA promoter in breast cancer

Y. Ji, Jin, H. H., Wang, M. D., Cao, W. X., Bao, J. L., Ji, Y., Jin, H. H., Wang, M. D., Cao, W. X., Bao, J. L., Ji, Y., Jin, H. H., Wang, M. D., Cao, W. X., and Bao, J. L., “Methylation of the RASSFIA promoter in breast cancer”, vol. 15. p. -, 2016.

RETRACTION of “Methylation of the RASSFIA promoter in breast cancer” by Y. Ji, H.H. Jin, M.D. Wang, W.X. Cao, J.L. Bao - Genet. Mol. Res. 15 (2): gmr.15028261 (2016) - DOI: 10.4238/gmr.15028261

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