Breast cancer

S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation

Y. J. Sun, Wang, X. K., and Li, B. J., S-phase kinase-associated protein 2 expression interference inhibits breast cancer cell proliferation, vol. 14, pp. 9244-9252, 2015.

We investigated the expression of S-phase kinase-associated protein 2 (SKP2) in breast cancer tissues, and the effects of SKP2-specific small interfering RNA (siRNA) interference on breast cancer cell proliferation. Thirty subjects provided breast cancer tissue samples and 18 subjects provided normal breast specimens for this study. The expression of SKP2 in breast cancer patient tissues and normal breast tissues was detected by western blotting analysis and reverse transcription-polymerase chain reaction.

Predictive potential role of glutathione S-transferase polymorphisms in the prognosis of breast cancer

X. Wang and Huang, Z. H., Predictive potential role of glutathione S-transferase polymorphisms in the prognosis of breast cancer, vol. 14, pp. 10236-10241, 2015.

The current study aimed at evaluating the associa­tion between GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms and clinical response to chemotherapy and treatment outcome of breast cancers patients. Genotyping of GSTP1 rs1695, GSTT1 deletion, and GSTM1 deletion was performed by Polymerase Chain Reaction Restriction Fragment Length Polymor­phism (PCR-RFLP) assay.

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