Breast cancer

Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China

S. Y. Yang, Aisimutula, D., Li, H. F., Hu, Y., Du, X., Li, J., and Luan, M. X., Mutational analysis of BRCA1/2 gene and pathologic characteristics from Kazakh population with sporadic breast cancer in northwestern China, vol. 14, pp. 13151-13161, 2015.

Mutations in the BRCA1/2 genes are associated with an increased risk of breast cancer, but no large-scale research have examined the BRCA1/2 mutations in Chinese Kazakh women. We evaluated the frequency and distributions of BRCA1 and BRCA2 gene mutations in Kazakh sporadic breast cancer patients and healthy women in China. The association between the clinical-pathologic features of Kazakh breast cancer patients and BRCA1/2 mutations were also investigated.

Study of PIK3CA, BRAF, and KRAS mutations in breast carcinomas among Chinese women in Qinghai

Y. L. Wang, Dai, X., Li, Y. D., Cheng, R. X., Deng, B., Geng, X. X., and Zhang, H. J., Study of PIK3CA, BRAF, and KRAS mutations in breast carcinomas among Chinese women in Qinghai, vol. 14, pp. 14840-14846, 2015.

Phosphatidylinositol-3-OH kinase and RAS-activated signaling pathways play an important role in tumor formation. Abnormalities in relevant genes play essential roles in the occurrence and development of many human cancers. Studies of breast cancer have mainly focused on the women in western countries, but few studies have examined the frequency of mutations in PIK3CA, BRAF, and KRAS in Chinese breast cancer patients.

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