Brain-derived neurotrophic factor

Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma

J. Y. Wang, Wang, A. L., Han, W., and Mu, Z. L., Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma, vol. 14, pp. 16233-16240, 2015.

Brain-derived neurotrophic factor (BDNF) promotes synaptic remodeling and modulates the function of other neurotransmitters. Allergic inflammation triggers neuronal dysfunction and structural changes in the airways. Genetic polymorphisms in functional regions of the BDNF gene have a plausible role in modulating the risk of child asthma (CA). This study examined the potential association between CA and three single nucleotide polymorphisms (SNPs) in BDNF (rs2030323, rs6265, and rs16917204 in the promoter, exon 4, and 3'-untranslated regions, respectively).

Subscribe to Brain-derived neurotrophic factor