Bone tissue engineering

Repairing rabbit radial defects by combining bone marrow stroma stem cells with bone scaffold material comprising a core-cladding structure

H. Wu, Liu, G. H., Wu, Q., and Yu, B., Repairing rabbit radial defects by combining bone marrow stroma stem cells with bone scaffold material comprising a core-cladding structure, vol. 14, pp. 11933-11943, 2015.

We prepared a bone scaffold material comprising a PLGA/β-TCP core and a Type I collagen cladding, and recombined it with bone marrow stroma stem cells (BMSCs) to evaluate its potential for use in bone tissue engineering by in vivo and in vitro experiments. PLGA/β-TCP without a cladding was used for comparison. The adherence rate of the BMSCs to the scaffold was determined by cell counting. Cell proliferation rate was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method.

Biocompatibility of differently proportioned HA/PLGA/BMP-2 composite biomaterials in rabbits

H. X. Cui, Guo, J., Han, Z., Guo, Y. X., and Guo, M. L., Biocompatibility of differently proportioned HA/PLGA/BMP-2 composite biomaterials in rabbits, vol. 14, pp. 13511-13518, 2015.

The aim of this study was to assess the histocompatibility of hydroxyapatite (HA)/poly(lactic-co-glycolic acid) (PLGA)/bone morphogenetic protein-2 (BMP-2) composite materials in rabbits. Thirty healthy New Zealand white rabbits were randomly divided into 3 groups (N = 10). HA/PLGA/BMP-2 composite materials with the HA/PLGA proportions of 1:1, 1:2, and 1:3 were implanted in the animals, which were subsequently sacrificed on the 30th and 60th days post-implantation to allow for differences in routine blood and biochemical indices to be assessed between the animal groups.

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