Bone mesenchymal stem cells

Use of bone mesenchymal stem cells to treat rats with acute liver failure

S. F. Yuan, Jiang, T., Sun, L. H., Zheng, R. J., Cao, G. Q., Ahat, N. Z., and Zhang, Y. X., “Use of bone mesenchymal stem cells to treat rats with acute liver failure”, vol. 13, pp. 6962-6980, 2014.

This study aimed to isolate mesenchymal stem cells from bone mesenchymal stem cells (BMSCs), determine their therapeutic potential for treating rats with acute liver failure (ALF), further explore the factors that induce liver failure mechanisms, and elucidate the role of bone marrow stem cell therapy and BMSCs on liver homing. We found that differentiation potential was present in BMSCs expressing high levels of CD29 and CD90.

Oct4 and Sox2 overexpression improves the proliferation and differentiation of bone mesenchymal stem cells in Xiaomeishan porcine

Y. X. Fan, Gu, C. H., Zhang, Y. L., Zhong, B. S., Wang, L. Z., Zhou, Z. R., Wang, Z. Y., Jia, R. X., and Wang, F., “Oct4 and Sox2 overexpression improves the proliferation and differentiation of bone mesenchymal stem cells in Xiaomeishan porcine”, vol. 12, pp. 6067-6079, 2013.

Mesenchymal stem cells derived from bone marrow (BMSCs) are a population of self-renewing multipotent cells that are capable of differentiating into various cellular lineages, and are widely employed in tissue engineering and cell therapy. Recently, clinical research involving BMSCs has become increasingly popular. In order to conduct appropriate research, it is first necessary to amplify large amounts of functional BMSCs in vitro. However, after several passages of expanding in vitro, the proliferation and differentiation potential of BMSCs gradually decline.

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