Biomarkers

Novel bioinformatic identification of differentially expressed tissue-specific and cancer-related proteins from the Human Protein Atlas for biomarker discovery

X. - X. Liu and Liu, F. - J., Novel bioinformatic identification of differentially expressed tissue-specific and cancer-related proteins from the Human Protein Atlas for biomarker discovery, vol. 14, pp. 4557-4565, 2015.

Identification of cancer-associated and tissue-specific proteins is important for research on carcinogenesis mechanisms and biomarker discovery. Here we performed a new strategy to identify candidate cancer proteins by mining immunohistochemistry protein profiles. Proteins with quantitative values from 14 normal tissues and their corresponding cancer tissues were compared and analyzed using bioinformatics.

Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang

L. Zhang, Sun, J., Zhang, J. Q., Yang, M., Bai, G., and Ma, X. L., Expression and significance of molecular biomarkers in esophageal carcinoma in different nationalities patients in Xinjiang, vol. 13, pp. 5413-5425, 2014.

This study aimed to explore some useful biomarkers to focus on the diagnosis and therapy response judgment in esophageal squamous cell carcinoma in Xinjiang. We used enzyme-linked immunosorbent method and immunohistochemistry to detect the expression of VEGF, EGFR, ES, HER-2, and NF-κBp in the serum and tissue with esophageal squamous cell carcinoma, and to analyze the relationship between biomarkers and clinical pathology and curative effects. Our findings were as follows: 1.

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