Biomarker

Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer

P. Liu, Xin, F., and Ma, C. F., Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer, vol. 14, pp. 17995-18002, 2015.

Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy volunteers were recruited. Quantitative reverse transcription-polymerase chain reaction was performed to compare the serum levels miR-196a in all participants.

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