Biochemical recurrence

Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population

M. Chen, Zhou, Z. Y., Chen, J. G., Tong, N., Chen, S. Q., Yang, Y., Zhang, X. W., Jiang, H., Liu, N., Liu, J., Sha, G. Z., Zhu, W. D., Hua, L. X., Wang, Z. J., and Xu, B., Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population, vol. 13, pp. 10615-10621, 2014.

Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy. Seventy-two southern Chinese with prostate cancer undergoing radical prostatectomy were included in this study. miR-146a polymorphism was analyzed by PCR-RFLP. Its prognostic role in biochemical recurrence was assessed using Kaplan-Meier analysis and Cox regression model.

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