Benign prostatic hyperplasia

Association of LTβR gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population

S. H. Lee, Kim, S. K., Yoo, K. H., Chung, J. H., and Chang, S. G., “Association of LTβR gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population”, vol. 14, pp. 18607-18615, 2015.

The lymphotoxin-β receptor (LTβR) gene is involved in autoimmune disease and inflammatory disorder development, but the relationship between LTβR and benign prostatic hyperplasia (BPH) is unclear. In total, 222 with BPH were examined for 3 single nucleotide polymorphisms [rs3759333 (-1387C/T), rs3759334 (-1326A/G), and rs2364480 (Ala172Ala)] located in the promoter and coding regions of LTβR using direct sequencing.

Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese

L. .Xiao, Gao, L. B., and Wei, Q., “Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese”, vol. 14, pp. 10682-10691, 2015.

The aim of this study was to determine the relationship between polymorphisms in the IL-28B and IL-28R genes and lower urinary tract symptoms (LUTS) in Chinese patients. Genomic DNA was extracted from 553 whole blood samples from 233 patients with LUTS resulted from benign prostatic hyperplasia and 320 control subjects. The IL-28B rs12979860 and rs8099917, and IL-28Rα rs10903035 and rs11249006 polymorphisms were genotyped using a polymerase chain reaction-restriction fragment length polymorphism assay.

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