Bcl-2

Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax

Y. Wei, Yuan, F. J., Zhou, W. B., Wu, L., Chen, L., Wang, J. J., Zhang, Y. S., Wei, Y., Yuan, F. J., Zhou, W. B., Wu, L., Chen, L., Wang, J. J., and Zhang, Y. S., Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax, vol. 15, p. -, 2016.

Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects of borax. However, the specific mechanisms regulating this effect are poorly understood. This study aimed to investigate the pathways underlying the growth inhibition induced by borax in HepG2 cells. The effects of borax on HepG2 cell viability were characterized using MTT. Apoptosis was also verified by annexin V/propidium iodide staining.

Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis

X. L. Zhou and Wang, M., Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis, vol. 14, pp. 17059-17067, 2015.

Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of three proteins and their correlation with metastasis in cervical cancer by comparing them in different cervical lesions.

Neuroprotective effects of Bcl-2 overexpression on nerve cells of rats with acute cerebral infarction

H. R. Zhang, Peng, J. H., Zhu, G. Y., and Xu, R. X., Neuroprotective effects of Bcl-2 overexpression on nerve cells of rats with acute cerebral infarction, vol. 14, pp. 7696-7703, 2015.

We aimed to investigate the influence of lentiviral-medi­ated Bcl-2 overexpression in cerebral tissues of rats with acute cerebral infarction. Forty-five rats were randomly divided into sham, model, and treatment groups. The sham and model groups were administered a control lentiviral vector via the intracranial arteries 10 days before surgery, while the treatment group received lentivirus encoding a Bcl-2 overexpression vector.

Effect of montelukast on the expression of interleukin-18, telomerase reverse transcriptase, and Bcl-2 in the brain tissue of neonatal rats with hypoxic-ischemic brain damage

J. L. Liu, Zhao, X. H., Zhang, D. L., Zhang, J. B., and Liu, Z. H., Effect of montelukast on the expression of interleukin-18, telomerase reverse transcriptase, and Bcl-2 in the brain tissue of neonatal rats with hypoxic-ischemic brain damage, vol. 14, pp. 8901-8908, 2015.

The aim of this study was to investigate the effect of mon­telukast on the expression of interleukin (IL)-18, telomerase reverse tran­scriptase (TERT), and Bcl-2 in the brain tissue of neonatal rats with hypox­ic-ischemic brain damage (HIBD). To establish the model of HIBD, 8% oxygen was applied to rats after the unilateral carotid artery was ligated. Twenty rats were randomly assigned to the control group, while another 40 were used to establish the HIBD model and were randomly divided equally into model group and treatment group.

Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells

D. X. Li, Zhang, J., Zhang, Y., Zhao, P. W., and Yang, L. M., Inhibitory effect of berberine on human skin squamous cell carcinoma A431 cells, vol. 14, pp. 10553-10568, 2015.

Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells.

Subscribe to Bcl-2