Base excision repair

XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people

X. Wang, Ma, K. W., Zhao, Y. G., Wang, G. J., and Li, W., XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people, vol. 14, pp. 15530-15538, 2015.

Base excision repair (BER) plays an important role in maintaining genome integrity and anti-cancer drug resistance. Single nu­cleotide polymorphisms (SNPs) in BER genes were detected in 500 lung cancer patients and 500 cancer-free controls. A logistic regression model was applied to analyze the relationship between lung cancer susceptibility and BER SNPs coupled with a wide range of epidemiological factors in a Chinese population.

Isolation and characterization of HC1: a novel human DNA repair gene

D. O. Lopes, Falconi, F. C., Goes, A. M., Canitrot, Y., Hoffmann, J. S., Cazaux, C., Franco, G. R., Macedo, A. M., Pena, S. D. J., and Machado, C. R., Isolation and characterization of HC1: a novel human DNA repair gene, vol. 8, pp. 247-260, 2009.

Nucleotide excision repair (NER) acts on a broad spectrum of large lesions, while base excision repair removes individual modified bases. Although both processes have been well studied in human cells, novel genes involved in these DNA repair pathways have been described. Using a heterologous complementation approach, we identified a fetal human cDNA that complemented two Escherichia coli mutants that are defective in 3-methyl adenine glycosylase and in three endonucleases, all of which are enzymes with important roles in base excision repair.

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