Autophagy

Association of Beclin-1 and microRNA-30a expression with the severity and treatment response of colorectal cancer

L. Liu, Meng, T., Wang, Q. S., Jin, H. Z., Sun, Z. Q., Jin, B., Fang, F., Wang, H. J., Liu, L., Meng, T., Wang, Q. S., Jin, H. Z., Sun, Z. Q., Jin, B., Fang, F., Wang, H. J., Liu, L., Meng, T., Wang, Q. S., Jin, H. Z., Sun, Z. Q., Jin, B., Fang, F., and Wang, H. J., “Association of Beclin-1 and microRNA-30a expression with the severity and treatment response of colorectal cancer”, vol. 15, p. -, 2016.

We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance of Beclin-1 in CRC, while the weak expression of Beclin-1 in normal tissue was used as the basis for assessing tumors (control group). Real-time reverse transcription-polymerase chain reaction quantified miR-30a levels.

Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin

W. M. Lin and Li, Z. G., “Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin”, vol. 14, pp. 16905-16912, 2015.

Development of chemoresistance is a major obstacle that leads to the recurrence and progression of cervical cancer (CC). Autophagy, meaning, “eating of self”, has shown paradoxical functions in tumors. In this study, we first investigated the process of autophagy induction by cisplatin in CC cells. Next, we investigated the role of autophagy in cisplatin-sensitivity of CC cells via blockage of cisplatin-induced autophagy.

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