Autophagy

Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin

W. M. Lin and Li, Z. G., Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin, vol. 14, pp. 16905-16912, 2015.

Development of chemoresistance is a major obstacle that leads to the recurrence and progression of cervical cancer (CC). Autophagy, meaning, “eating of self”, has shown paradoxical functions in tumors. In this study, we first investigated the process of autophagy induction by cisplatin in CC cells. Next, we investigated the role of autophagy in cisplatin-sensitivity of CC cells via blockage of cisplatin-induced autophagy.

Autophagy in drug resistance of the multiple myeloma cell line RPMI8226 to doxorubicin

Y. - Z. Pan, Wang, X., Bai, H., Wang, C. - B., Zhang, Q., and Xi, R., Autophagy in drug resistance of the multiple myeloma cell line RPMI8226 to doxorubicin, vol. 14, pp. 5621-5629, 2015.

We investigated the effect of autophagy on drug resistance of multiple myeloma (MM) to doxorubicin (DOX). A DOX-resistant MM cell line (RPMI8226/DOX) was developed by progressively increasing the DOX concentration gradient. The drug resistance index was determined using the MTT method. Transmission electron microscopy, anti-light chain 3-fluorescein isothiocyanate immunofluorescence, and Western blotting were used to detect autophagy of MM cells.

Regulation of ATG6/Beclin-1 homologs by abiotic stresses and hormones in rice (Oryza sativa L.)

R. M. Rana, Dong, S., Ali, Z., Huang, J., and Zhang, H. S., Regulation of ATG6/Beclin-1 homologs by abiotic stresses and hormones in rice (Oryza sativa L.), vol. 11, pp. 3676-3687, 2012.

Autophagy, a complex and conserved mechanism, serving as a defense response in all eukaryotic organisms, is regulated by several proteins, among which ATG proteins are the most important due to their involvement in autophagosome formation. ATG6/Beclin-1 proteins, reported to be essential for autophagosome formation and assigned as a conserved domain, were subjected to database searches. We found three homologs in the rice (Oryza sativa) genome.

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