Auraptene

Rapid and sensitive LC-MS/MS method for the determination of auraptene in rat plasma and its application in a pharmacokinetic and bioavailability study in rats

X. D. Ye, Ouyang, H., Zhong, L. Y., Li, T. E., Rao, X. Y., Feng, Y. L., Yang, W. L., Ye, X. D., Ouyang, H., Zhong, L. Y., Li, T. E., Rao, X. Y., Feng, Y. L., and Yang, W. L., Rapid and sensitive LC-MS/MS method for the determination of auraptene in rat plasma and its application in a pharmacokinetic and bioavailability study in rats, vol. 15, p. -, 2016.

A simple, sensitive and specific liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of auraptene, a constituent isolated from Fructus aurantii with potential to combat Alzheimer’s disease, in rat plasma. Rat plasma samples were pretreated by protein precipitation with methanol. The analytes were separated by a Waters Sun Fire C18 column (50 mm x 2 mm, 5 μm) and eluted with 1:1000 methanol and formic acid/water (v/v) mobile phase with a flow rate of 0.5 mL/min.

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