Atorvastatin

Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure

H. Y. Duan, Liu, D. M., Qian, P., Wang, S. L., Yan, L. J., Wu, J. T., Yang, H. T., Fan, X. W., and Chu, Y. J., Effect of atorvastatin on plasma NT-proBNP and inflammatory cytokine expression in patients with heart failure, vol. 14, pp. 15739-15748, 2015.

The aim of this study was to explore the effect of atorvastatin intervention on plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory cytokine levels in patients with heart failure (HF). One hundred and twenty-three HF patients were selected from our hospital and randomly divided into control (N = 61) and observation (N = 62) groups; the former received conventional treatment, while the latter were given conventional treatment combined with atorvastatin.

Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions

M. C. Bi, Song, X. J., Shi, H., Xue, W. X., Xu, C. L., and Song, E., Effect of atorvastatin on diabetic rat endothelial cells and retinal lesions, vol. 14, pp. 5462-5467, 2015.

We investigated the effect of atorvastatin on vascular endothelial growth inhibitor (VEGI) expression in rats with diabetic retinopathy. Wistar rats were divided into a blank group and diabetic model group, which was further randomly divided into treatment and control groups. Rats in the treatment group received 10 mg/kg atorvastatin daily, while rats in the blank and control groups received normal saline. Rats were randomly euthanized at 3 or 6 months.

Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease

J. Li, Zhang, L., Xie, N. Z., Deng, B., Lv, L. X., and Zheng, L. Q., Relationship between the cholesterol ester transfer protein TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease, vol. 13, pp. 2140-2148, 2014.

This study aimed to investigate the relationship between the cholesterol ester transfer protein (CETP) gene TaqIB polymorphism and the lipid-lowering effect of atorvastatin in patients with coronary atherosclerotic heart disease. Two hundred eighty-eight patients were divided into a control group, an acute coronary syndrome (ACS) group, and a stable coronary heart disease (CHD) group.

Effect of atorvastatin on vascular endothelial function in moderately nicotine-dependent smokers

X. Z. Cao, Luo, Z. R., Zhang, H. M., and Cai, J. Q., Effect of atorvastatin on vascular endothelial function in moderately nicotine-dependent smokers, vol. 13, pp. 2698-2702, 2014.

We investigated the effect of atorvastatin on vascular endothelial function in moderately nicotine-dependent smokers. One hundred and sixty moderately nicotine-dependent smokers were randomly divided into the atorvastatin group (N = 80) and the control group (N = 80).

Effects of atorvastatin in combination with ezetimibe on carotid atherosclerosis in elderly patients with hypercholesterolemia

P. Luo, Li, L., Wang, L. X., Zhu, H. H., Du, S., Wu, S. L., Han, Y. G., and Wang, G. G., Effects of atorvastatin in combination with ezetimibe on carotid atherosclerosis in elderly patients with hypercholesterolemia, vol. 13, pp. 2377-2384, 2014.

The aim of this study was to observe the effects of atorvastatin combined with ezetimibe on carotid atherosclerosis in elderly patients with hypercholesterolemia. A total of 84 elderly hypercholesterolemic patients complicated with carotid atherosclerosis were divided into control group (atorvastatin alone) and combined group (atorvastatin combined with ezetimibe) and treated for 12 months. Carotid atherosclerosis-related indicators including blood lipid and high-sensitivity C-reactive protein (hsCRP) were determined before and after treatment.

Protection effect of atorvastatin in cerebral ischemia-reperfusion injury rats by blocking the mitochondrial permeability transition pore

T. Song, Liu, J., Tao, X., and Deng, J. G., Protection effect of atorvastatin in cerebral ischemia-reperfusion injury rats by blocking the mitochondrial permeability transition pore, vol. 13, pp. 10632-10642, 2014.

The aim of this study was to investigate the influence of atorvastatin on the opening of the mitochondrial permeability transition pore (MPTP) and the expression of cytochrome C (Cyt C) in Sprague-Dawley rats with cerebral ischemia-reperfusion (I/R). The rat model of cerebral artery ischemia was established by the suture-occluded method with ischemia for 2 h and reperfusion for 72 h.

Effect of atorvastatin on left atrial function of patients with paroxysmal atrial fibrillation

Y. D. Li, Tang, B. P., Guo, F., Li, J. X., Han, W., Tang, Q., and Zhang, Y. Y., Effect of atorvastatin on left atrial function of patients with paroxysmal atrial fibrillation, vol. 12, pp. 3488-3494, 2013.

The aim of this study was to evaluate the effects of atorvastatin on left atrial (LA) function in paroxysmal atrial fibrillation patients. Fifty-eight paroxysmal atrial fibrillation patients were divided into two groups (treatment and control groups). The echocardiography parameters, including LA active emptying volume (LAAEV), LA active emptying fraction, LA maximum volume, LA total emptying volume, LA total emptying fraction, and LA ejection force (LAEF), were measured before treatment, and then 12 and 18 months after treatment.

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