Atherosclerosis

Prediction of genetic risk factors of atherosclerosis using various bioinformatic tools

H. X. Wang, Zhao, Y. X., Wang, H. X., Zhao, Y. X., Wang, H. X., and Zhao, Y. X., “Prediction of genetic risk factors of atherosclerosis using various bioinformatic tools”, vol. 15, p. -, 2016.

The aim of this study was to identify potential markers of atherosclerosis development in familial hypercholesterolemia (FH) patients. GSE13985 microarray data, generated using blood samples from 5 FH patients and 5 matched controls, was downloaded from the Gene Expression Omnibus. Differentially expressed genes (DEGs) between FH and controls were identified and a protein-protein interaction (PPI) network was constructed. Module and hub proteins were screened in this network.

Interleukin-4 regulates macrophage polarization via the MAPK signaling pathway to protect against atherosclerosis

X. N. Zhao, Li, Y. N., Wang, Y. T., Zhao, X. N., Li, Y. N., and Wang, Y. T., “Interleukin-4 regulates macrophage polarization via the MAPK signaling pathway to protect against atherosclerosis”, vol. 15, p. -, 2016.

Our study aimed to investigate the effects of interleukin-4 (IL-4) on macrophage polarization, as well as its role in the development of atherosclerosis. Human peripheral blood mononuclear cells (PBMCs) were isolated and randomly divided into 3 groups: control group, ox-LDL group, and ox-LDL + IL-4 groups. The expression of M1/M2 macrophage surface markers such as TNF-α, CD68, and CD206 were analyzed by western blot. Cell viability was determined using the MTT assay. Measurement of CD86/CD206 expression ratio (M1/M2 ratio) was performed via flow cytometry.

Effect of GBOT on blood lipid and blood glucose metabolism in rats with atherosclerosis

A. Rong, Borjihan, G., and Qiao, Y. J., “Effect of GBOT on blood lipid and blood glucose metabolism in rats with atherosclerosis”, vol. 14, pp. 7801-7810, 2015.

We observed the variation in in vivo blood lipid and blood glucose metabolism in rats with atherosclerosis after 5-(3,4-dihydroxy-phenyl)-1-piperidin-1-yl-penta-2,4-dien-1-one (GBOT) administration. Wistar rats aged 10 weeks received a high-fat diet to establish the atherosclerosis model. Metabolic indices related to blood lipid and blood glucose were measured before modeling and at 4 and 8 weeks after modeling. Liver fat levels in rats were measured at 8 weeks to analyze the relationship between liver fat and blood lipid levels.

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