Atherosclerosis

Protective effect of the polarity of macrophages regulated by IL-37 on atherosclerosis

J. Huang, Hou, F. L., Zhang, A. Y., Li, Z. L., Huang, J., Hou, F. L., Zhang, A. Y., and Li, Z. L., Protective effect of the polarity of macrophages regulated by IL-37 on atherosclerosis, vol. 15, p. -, 2016.

As an anti-inflammatory cytokine, interleukin-37 (IL-37) provides certain protective effects against inflammatory and autoimmune diseases. Recent reports indicate that IL-37 is expressed in foam cells of atherosclerotic plaques in both the coronary and carotid arteries of humans, suggesting the possible involvement of IL-37 in the pathogenesis and progression of atherosclerosis. Current evidence supports the protective role that IL-37 plays against atherosclerosis via the regulation of different subtypes of macrophage.

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