Asthma

Association between the interleukin 4 gene -590C>T promoter polymorphism and asthma in Xinjiang Uighur children

J. H. Zhang, Zhou, G. H., Wei, T. T., Chang, Z. S., Zhang, J. H., Zhou, G. H., Wei, T. T., and Chang, Z. S., Association between the interleukin 4 gene -590C>T promoter polymorphism and asthma in Xinjiang Uighur children, vol. 15, p. -, 2016.

We investigated the association between the interleukin 4 gene (IL-4) -590C>T polymorphism and forced expiratory volume in one second (FEV1) values, immunoglobulin E (IgE) levels, and susceptibility to asthma in Uighur children. IL-4 -590C>T frequencies were analyzed in 38 bronchial asthmatic patients and 35 non-asthmatic controls. Polymerase chain reaction and direct sequencing were applied to determine the residue at position -590 of IL-4.

Expression of M3 acetylcholine receptor in asthmatic mice and bronchial airway remodeling prediction

F. Zhao, Yang, J., Chen, P., Wang, Y., Zhang, H., Zhang, Q., Zhao, F., Yang, J., Chen, P., Wang, Y., Zhang, H., and Zhang, Q., Expression of M3 acetylcholine receptor in asthmatic mice and bronchial airway remodeling prediction, vol. 15, p. -, 2016.

This study aimed to investigate the role of M3 acetylcholine receptor (M3-AChR) expression in airway remodeling. Additionally, we aimed to evaluate the effects of ipratropium bromide solution inhaled in an early phase of asthma on airway remodeling in ovalbumin (OVA)-sensitized and challenged mice. Thirty BALB/c mice were divided into three groups, namely, control group (saline sensitized/challenged mice), asthma group (OVA sensitized/challenged mice), and treatment group (OVA sensitized/challenged mice treated by ipratropium bromide).

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